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. 2017 May 15;10:129. doi: 10.3389/fnmol.2017.00129

Figure 2.

Figure 2

Metabolic and behavioral changes induced by endogenous vs. exogenous ketosis. Intragastric administration of exogenous ketones (mixture of KetoCaNa + Caprylic Triglyceride, CT) induces a reduction in blood glucose (A) while increasing and sustaining higher blood ketone levels for up to 4 h (B). (C) No differences in body weight gain were observed during baseline assessment or transition into new diets whereas decreased body weight gain was observed in KD-fed rats following the start of dietary interventions. (D) KD-fed rats showed slower weight gain compared to control or KS diets after onset of chronic administration. (E) Blood glucose levels were significantly reduced in KD group 1 week after the start of dietary treatment. (F) KD feeding resulted in significantly elevated blood levels of the ketone body β-hydroxybutyrate (BHB) starting 1 week following dietary treatments. (G) Blood insulin levels at week 1 were significantly decreased in KD group. Data presented as mean ± S.E.M. (n = 6–8/group). *p ≤ 0.05; **p < 0.01; ***p < 0.001.