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. 2017 May 15;8:872. doi: 10.3389/fmicb.2017.00872

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Copyright © 2017 Hajam and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specific antibody titers in mice (n = 6) after vaccination with JOL1913+1917. Mice were either immunized intramuscularly with the PBS only, JOL1837 carrying the empty vector pJHL65 (Sal-vector) and constructs JOL1913+JOL1917 (im-Sal-HA-M2e), or intraperitoneally with JOL1913+JOL1917 (ip-Sal-HA-M2e) or orally with constructs JOL1913+1917 (po-Sal-HA-M2e). Serum samples were analyzed for HI activity after 28 days post-vaccination. Each data points represent mean ± S.D. ^∗∗p < 0.01; ns, non-significant.