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. 2017 May 15;8:295. doi: 10.3389/fphys.2017.00295

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Copyright © 2017 Keshavarz, Schwarz, Hartmann, Wiegand, Skill, Althaus, Kummer and Krasteva-Christ.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5-HT-mediated changes in the luminal area of peripheral bronchi from cav-1^−/− mice after treatment with vehicle or with the 5-HT2A receptor antagonist, ketanserin. (A) Changes in the luminal area of mouse peripheral airways was recorded by videomorphometry in PCLS after cumulative application of different concentrations of 5-HT and KCl. 5-HT induces a decrease in luminal airway area in cav-1^−/− mice. (B) Sigmoidal concentration-response curves for 5-HT were plotted according to the Hill equation in the presence of the different doses of ketanserin and the pA2-value for ketanserin (8.689) was estimated by Schild-analysis. Hill-slope and Schild-slope were fixed to 1.0. Data are presented as mean of number of animals (n) ± SEM.