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. 2017 May 15;8:295. doi: 10.3389/fphys.2017.00295

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Copyright © 2017 Keshavarz, Schwarz, Hartmann, Wiegand, Skill, Althaus, Kummer and Krasteva-Christ.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5-HT-mediated changes in constrictor force and reactivity of different parts of the trachea and extrapulmonary bronchi from cav-1^+/+ and cav-1^−/− mice. Organ bath recordings, each point represents the mean of number of animals (n) ± SEM. (A,B) Changes in the force were recorded after cumulative application of different concentrations of 5-HT. Following equilibration, baseline tension was adjusted to 0.5 g for all airway segments in all preparations. Baseline was set as 100% and the maximum response at each concentration was evaluated. 5-HT induces concentration-dependent contraction in main bronchus, tracheal middle and caudal parts in cav-1^+/+ mice (A), whereas the cranial part of cav-1^+/+ mice and all tracheal parts and bronchi of cav-1^−/− mice are not responsive to 5-HT (A,B). (C,D) Comparison of constrictor response between both mouse strains. Note that means are not defined (and left blank) when values are 0 or negative.