Table 1.
Clinical and smoking characteristics of lung cancer patients with brain metastases receiving intracranial stereotactic radiosurgery stratified by histology (N = 366)
| Adenocarinoma | Nonadenocarcinoma | P | |
|---|---|---|---|
| n = 218 | n = 148 | ||
| Age (median [range]) | 63.00 [31.00, 87.00] | 64.00 [33.00, 88.00] | 0.53 |
| Male gender (%) | 120 (55) | 79 (53) | 0.84 |
| Number of brain metastases (%) | 0.22 | ||
| 1 | 106 (49) | 83 (56) | |
| 2 | 45 (21) | 34 (23) | |
| 3 | 34 (16) | 17 (12) | |
| 4 + | 33 (15) | 14 (9.5) | |
| Systemic disease burden (%) | 0.52 | ||
| None | 49 (23) | 31 (21) | |
| Oligometastatic | 107 (49) | 80 (54) | |
| Unknown | 4 (1.8) | 5 (3.4) | |
| Widespread | 58 (27) | 32 (22) | |
| Systemic disease status (%) | 0.40 | ||
| Progressive | 71 (33) | 44 (30) | |
| Stable | 132 (61) | 88 (60) | |
| Unknown | 15 (6.9) | 16 (11) | |
| KPS (%) | 0.30 | ||
| 50 | 1 (0.50) | 0 (0.0) | |
| 60 | 14 (6.4) | 16 (11) | |
| 70 | 34 (16) | 18 (12) | |
| 80 | 96 (44) | 69 (47) | |
| 90 | 69 (32) | 39 (26) | |
| 100 | 4 (1.8) | 6 (4.1) | |
| DSGPA (%) | 0.47 | ||
| 0 | 3 (1.4) | 0 (0.0) | |
| 0.5 | 9 (4.1) | 10 (6.8) | |
| 1 | 41 (19) | 28 (19) | |
| 1.5 | 65 (30) | 41 (28) | |
| 2 | 37 (17) | 29 (20) | |
| 2.5 | 34 (16) | 23 (16) | |
| 3 | 22 (10) | 9 (6.1) | |
| 3.5 | 6 (2.8) | 8 (5.4) | |
| 4 | 1 (0.50) | 0 (0.0) | |
| Smoking Status (%) | 0.40 | ||
| Current | 77 (36) | 60 (41) | |
| Noncurrent | 135 (62) | 88 (59) | |
| Unknown | 2 (0.90) | 0 (0.0) | |
| Pack years (median [IQR]) | 40 [20, 50] | 40 [20, 50] | 0.60 |
| Metastasis number (median [range]) | 2.00 [1.00, 13.00] | 1.00 [1.00, 18.00] | 0.074 |
| Minimal_dose (median [range]) | 20.00 [11.00, 24.00] | 20.00 [10.00, 24.00] | 0.71 |
KPS, Karnofsky performance status; DS‐GPA, disease‐specific Graded Prognostic Assessment.