Representative images of Trop2 and AREG protein expression in gastric tissues TMA sections. (A)Gastric cancer with expression of Trop2 and AREG: (a1‐2) high expression of Trop2 immunohistochemistry (IHC score, 300); (a3‐4) high expression of AREG (IHC score, 80); (b1‐2) high expression of Trop2(IHC score, 200); (b3‐4)low expression of AREG (IHC score, 10);(c1‐2) low expression of Trop2(IHC score, 30) (c3‐4) high expression of AREG (IHC score, 150); (d1‐2) low expression of Trop2 (IHC score, 50) (d3‐4) low expression of AREG (IHC score, 50). (B) Matched adjacent tissue with expression of Trop2 and AREG: (a1‐2) high expression of Trop2 (IHC score, 200); (a3‐4) low expression of AREG (IHC score,50) (b1‐2) low expression of Trop2(IHC score, 60); (b3‐4)high expression of AREG (IHC score, 150);(c1‐2) low expression of Trop2(IHC score, 60) (c3‐4) low expression of AREG (IHC score, 0). (C) Chronic gastritis with expression of Trop2 and AREG: (a1‐2) high expression of Trop2 (IHC score, 150); (a3‐4) low expression of AREG (IHC score, 0); (b1‐2) low expression of Trop2 (IHC score, 100); (b3‐4) high expression of AREG (IHC score, 160); (c1‐2) low expression of Trop2 (IHC score, 30); (c3‐4)low expression of AREG (IHC score, 20). (D) Intestinal metaplasia with expression of Trop2 and AREG: (a1‐2) high expression of Trop2 (IHC score, 180); (a3‐4) high expression of AREG (IHC score, 200); (b1‐2) high expression of Trop2 (IHC score, 150); (b3‐4) low expression of AREG (IHC score, 10); (c1‐2) low expression of Trop2 (IHC score, 30); (c3‐4) low expression of AREG (IHC score, 10). (E) Intraepithelial neoplasia with expression of Trop2 and AREG: (a1‐2) high expression of Trop2 (IHC score, 200); (a3‐4) high expression of AREG (IHC score, 160); (b1‐2) high expression of Trop2 (IHC score, 200); (b3‐4) low expression of AREG(B3‐4) (IHC score, 10);(c1‐2) low expression of Trop2 (IHC score, 0); (c3‐4) high expression of AREG (IHC score, 130); (d1‐2) low expression of Trop2 (IHC score,10); (d3‐4) low expression of AREG (D3‐4) (IHC score, 0).