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. 2017 Apr 12;6(5):1072–1081. doi: 10.1002/cam4.1053

Figure 4.

Figure 4

Hypoxia induced up‐regulated AEG‐1 promoter activity via HIF‐1α. AEG‐1 luciferase construct was cotransfected in OVCAR3 cells. Cells were incubated under hypoxic/normoxic conditions for 24 hours. Luciferase activities of cell lysates were measured. Firefly luciferase activity was normalized to the activity of Renilla luciferase. Data given are mean ± SD, n = 3. **P <0.01, means versus negative control. ***P <0.001, means wild‐type AEG‐1 group under hypoxia versus normoxia group. # means there was no significant difference among AEG‐1 mutation group under hypoxia, wild‐type AEG‐1 and AEG‐mutation group under normoxia.