Figure 5.

Upregulated DRP5 proteins in tumor tissues of osteosarcoma patients implies poor clinical prognosis. Immunohistochemical staining was used to detect DRP5 protein expression in osteosarcoma tissues (n = 108). Representative negative and positive images are shown (A). ROC curve analysis was used to determine the cutoff value for high expression of the DRP5 protein in lung osteosarcoma tissues. The sensitivity and specificity for overall survival (B) and lung metastasis (C) were plotted. Kaplan–Meier analysis of overall survival (D) and lung metastasis‐free survival (E) with high or low DRP5 expression.