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. 2017 Apr 4;6(5):1023–1035. doi: 10.1002/cam4.1061

Figure 2.

Figure 2

NRAS‐mutation(+) CRC showed two major subtypes. After evaluating methylation epigenotype of CRC samples, all CRC samples were divided into three groups. While none of NRAS‐mutation(+) cases was equivalent to HME, 20 NRAS‐mutation(+) CRC were equivalent to IME CRC and 41 cases were equivalent to LME CRC (P = 0.008). NRAS‐mut(+),KRAS‐mut(+), or BRAF‐mut(+): samples positive for NRAS‐mutation, KRAS‐mutation, or BRAF‐mutation are shown in black. Blue: Group 1 markers. Orange: Group 2 markers.