Table 2.
Gene expression in epiWAT in C57Bl/6J and FVB/N mice that were fed the chow diet or HFD. Pparg2 (PPARγ2), peroxisome proliferator‐activated receptor γ2; Pgc1a (PGC1α), peroxisome proliferative activated receptor γ, coactivator 1α; Cebpa (C/EBPα), CCAAT/enhancer‐binding protein α; Srebp1 (SREBP‐1c), sterol regulatory element‐binding transcription factor 1c; Acaca (ACCα, acetyl‐CoA carboxylase α; Fasn (FAS), fatty acid synthase; Cpt1a (CPT‐I), carnitine palmitoyltransferase I; Lipe (HSL), hormone‐sensitive lipase; Ucp2, uncoupling protein 2; Pfk‐1, phosphofructokinase 1; Pck1 (PEPCKcit), phosphoenol pyruvate kinase cytosolic; Slc2a4 (GLUT4), glucose transporter type 4; Lep, leptin; Tnf (TNFα, tumor necrosis factor α; Il6 (IL6), interleukin 6. n = 9
| C57BL6/J Chow | C57BL6/J HFD | FVB/N Chow | FVB/N HFD | C57BL6/J | FVB/N | C57BL6/J vs. FVB/N | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Chow vs. HFD | Chow vs. HFD | ||
| Transcriptional factors | |||||||||||
| Pparg2 (PPARγ2) | 1.0 | 0.05 | 0.6 | 0.09 | 1.1 | 0.11 | 0.2 | 0.02 | P < 0.01 | P < 0.0001 | n.s. |
| Pgc1a (PGC1α) | 1.0 | 0.14 | 0.3 | 0.05 | 0.8 | 0.13 | 0.3 | 0.08 | P < 0.001 | P < 0.01 | n.s. |
| Cebpa (C/EBPα) | 1.0 | 0.07 | 0.6 | 0.05 | 0.8 | 0.07 | 0.2 | 0.02 | P < 0.0001 | P < 0.0001 | n.s. |
| Srebp1 (SREBP‐1c) | 1.0 | 0.11 | 0.9 | 0.09 | 1.4 | 0.13 | 2.1 | 0.23 | n.s. | P < 0.05 | P < 0.05 |
| Fatty acid metabolism | |||||||||||
| Acaca (ACCα) | 1.0 | 0.20 | 0.3 | 0.06 | 2.3 | 0.50 | 0.2 | 0.04 | P < 0.01 | P < 0.001 | P < 0.05 |
| Fasn (FAS) | 1.0 | 0.26 | 0.4 | 0.09 | 2.5 | 0.54 | 0.2 | 0.05 | P < 0.05 | P < 0.001 | P < 0.05 |
| Cpt1a (CPT‐I) | 1.0 | 0.24 | 1.7 | 0.20 | 2.8 | 0.29 | 6.2 | 0.73 | P < 0.05 | P < 0.001 | P < 0.001 |
| Lipe (HSL) | 1.0 | 0.08 | 0.6 | 0.08 | 1.0 | 0.13 | 0.1 | 0.02 | P < 0.01 | P < 0.0001 | n.s. |
| Ucp2 | 1.0 | 0.14 | 3.0 | 0.49 | 3.7 | 0.45 | 9.2 | 0.88 | P < 0.01 | P < 0.0001 | P < 0.0001 |
| Glucose metabolism | |||||||||||
| Pfk‐1 | 1.0 | 0.07 | 0.8 | 0.07 | 1.5 | 0.19 | 0.5 | 0.08 | n.s. | P < 0.001 | P < 0.05 |
| Pck1 (PEPCKcit) | 1.0 | 0.14 | 0.3 | 0.06 | 1.1 | 0.18 | 0.02 | 0.01 | P < 0.001 | P < 0.0001 | n.s. |
| Slc2a4 (GLUT4) | 1.0 | 0.06 | 0.4 | 0.06 | 1.2 | 0.22 | 0.05 | 0.01 | P < 0.0001 | P < 0.0001 | n.s. |
| Adipokines | |||||||||||
| Lep (Leptin) | 1.0 | 0.16 | 3.4 | 0.52 | 2.3 | 0.37 | 0.7 | 0.18 | P < 0.001 | P < 0.01 | P < 0.01 |
| Tnf (TNFα) | 1.0 | 0.38 | 4.8 | 1.74 | 1.9 | 0.39 | 19 | 2.84 | P < 0.05 | P < 0.0001 | n.s. |
| Il6 (IL6) | 1.0 | 0.49 | 4.1 | 0.76 | 2.8 | 0.40 | 9.0 | 1.71 | P < 0.01 | P < 0.01 | P < 0.05 |