Table 7.

Changes in expression of genes involved in estrogen biosynthesis and action according to histopathological and clinical characteristics of endometrial cancer patients.

	Histological grade (high gradevs.low grade)		FIGO stage (IAvs.IB-IV)	Menopausal status		Myometrial invasion (yes/no)	Myometrial invasion >1/2 (yes/no)	Lymphovascular invasion invasion (yes/no)
	Adj.p	p	p	Adj.p	p	p	p	Adj.p
AKR1C3	0.825	0.880	0.306	0.424	0.754	0.555	0.100	0.804	0.99
CYP19A1	0.712	0.876	0.219	0.011	0.176	0.883	0.068	0.680	0.989
HSD17B2	0.010	0.160	0.251	0.028	0.224	0.939	0.199	0.961	0.961
HSD17B1	0.019	0.101	0.288	0.741	0.847	0.060	0.690	0.075	0.600
HSD17B4	0.010	0.080	0.785	1	1	0.507	0.584	0.364	0.582
HSD17B8	0.507	0.676	0.891	0.317	0.845	0.338	0.273	0.117	0.624
HSD17B14	0.276	0.552	0.885	0.674	0.899	0.563	0.430	0.359	0.718
HSD17B12	0.210	0.480	0.946	0.463	0.741	0.606	0.273	0.215	0.491
SULT1E1	0.072	0.230	0.060	0.321	0.734	0.761	0.313	0.177	0.566
STS	0.457	0.665	0.915	0.706	0.869	0.580	0.084	0.912	1
SULT2A1	0.805	0.920	0.591	0.758	0.809	0.183	0.922	0.004	0.064
SULT2B1	0.044	0.176	0.737	0.132	0.528	0.493	0.495	0.361	0.642
ESR1	0.901	0.901	0.831	0.330	0.66	0.182	0.454	0.210	0.560
ESR2	0.333	0.592	0.738	0.113	0.603	0.739	0.255	0.150	0.600
GPER2	0.446	0.714	0.799	0.483	0.703	0.919	0.288	0.915	0.976
GPER34	0.186	0.496	1	0.268	0.858	0.416	0.507	0.71	0.947

Changes in gene expression ratios were tested using Mann-Whitney nonparametric tests for two-group comparisons, and Wilcoxon nonparametric W tests. Corrections for multiple testing were performed according to Benjamini and Hochberg [7]. Asymptotic 2-tailed significance (p) and adjusted significance (Adj. p) are shown. Adj. p was calculated only in the groups where p < 0.05.