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. 2017 May 11;10(4):469–475. doi: 10.1016/j.tranon.2017.03.001

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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(A) Detection of FGFR2 gene amplification in FGFR2-amplified PDCs by quantitative RT-PCR analysis. (B) The viability of FGFR2-amplified PDCs was measured by CTG assay after treatment with various concentrations of AZD4547 for 5 days. Cell viability (%) represents the percentage of growth compared to the control (no treatment). IC₅₀ values are 250 nM and 210 nM for PDC#1 and PDC#2, respectively. (C) Immunoblot assay for determining FGFR phosphorylation and targeted downstream pathways. Cells were treated with 1 μM AZD4547 for 5 days. Control cells were treated with DMSO.