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. 2017 Mar 23;595(10):3181–3202. doi: 10.1113/JP274015

Figure 7. The initial segment of the long‐NT α1C is essential for the I Ba enhancement by cAMP.

Figure 7

In this figure, LNT denotes the long‐NT initial segment of α1C encoded by exon 1a, and SNT denotes the short‐NT encoded by exon 1. A, regulation of chimeras and N‐terminal deletion mutants of rabbit α1CΔ1821 by cAMP (200 μm). Right panel, the N‐terminal amino acid sequences in α1CΔ1821 constructs used. Δ139 is a deletion of most of the NT, including exon 1a and most of exon 2. Colour codes: blue, SNT initial segment (encoded by exon 1); the other colours correspond to segments of the initial segment of LNT; first methionine is in black. Left panel shows the summary of cAMP effect (11 experiments). Statistical significance was determined by paired t test. *** P < 0.001; * P = 0.012; ns, not significant. B, representative time course charts of changes in I Ba following cAMP injection in some of the constructs. Insets show current traces in the same cells.