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. 2017 May 15;7:94. doi: 10.3389/fonc.2017.00094

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Copyright © 2017 Ionkina, Tentler, Kim, Capasso, Pitts, Ryall, Howison, Kabos, Sartorius, Tan, Eckhardt and Diamond.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Triple-negative breast cancer (TNBC) subtyping for CU_TNBC_002. We performed TNBC subtyping on the CU_TNBC_002 model and computed the correlation of this model at the pretreatment, sensitive on treatment and acquired resistance time points against the six TNBC subtypes. At the pretreatment and sensitive time points, we observed luminal androgen receptor (LAR) as the dominant subtype followed by BL2. However, at the acquired resistance time point, BL2 was the dominant subtype followed by LAR. This subtype switching suggests expansion of BL2 subtype at acquired resistance in this model.