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. 2017 Apr 19;7:957. doi: 10.1038/s41598-017-01109-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Liver transcriptome is distinctly altered by the Bcs1l mutation and the diet. (A) Principal component analysis of 500 most variable transcripts shows separation of WT and mutant mice (PC1) and partial separation of dietary groups and gender (PC2). (B) Heat map of differentially expressed genes. Nineteen genes had significant gender-genotype interaction (not shown in the heatmap) (C) A pathway analysis of the gene clusters. (D) The most significant transcriptional regulators predicted to drive the observed gene expression changes.