Table 1.
Biochemical parameters in whole blood and plasma, mean ± SD (n).
| Age (d) | WT | Bcs1l G/G | |||
|---|---|---|---|---|---|
| CD | KD | CD | KD | ||
| Whole blood | |||||
| Glucose (mmol/L) | 45 | 8.1 ± 1.3 (7) | 8.3 ± 1.3 (7) | 5.6 ± 2.0††† (9) | 5.0 ± 1.9 (7) |
| 95 | 8.9 ± 1.6 (8) | 10.3 ± 2.0 (9) | 4.7 ± 1.1††† (8) | 3.2 ± 1.1 (6) | |
| Lactate (mmol/L) | 45 | 3.2 ± 1.9 (9) | 2.7 ± 2.4 (7) | 5.0 ± 4.6 (9) | 3.1 ± 2.8 (8) |
| 95 | 8.8 ± 2.0 (8) | 4.3 ± 2.3 (9) | 6.5 ± 3.6 (8) | 8.1 ± 3.4 (6) | |
| Lactate to glucose ratio | 45 | 0.36 ± 0.22 (7) | 0.36 ± 0.32 (6) | 0.90 ± 0.84 (8) | 0.67 ± 0.68 (7) |
| 95 | 0.8 ± 0.3 (8) | 0.4 ± 0.3 (9) | 1.3 ± 0.6† (8) | 2.3 ± 0.9‡‡ (6) | |
| β-hydroxybutyrate (mmol/L) | 45 | 0.36 ± 0.3 (6) | 2.0 ± 0.6*** (3) | 0.58 ± 0.2 (4) | 4.8 ± 1.1‡‡‡ (3) |
| 95 | 0.58 ± 0.2 (8) | 0.67 ± 0.2 (9) | 0.87 ± 0.4 (8) | 4.9 ± 2.0‡‡ (6) | |
| Plasma | all 95 | ||||
| Alanine aminotransferase (U/L) | 42 ± 8 (5) | 88 ± 67 (5) | 260 ± 75††† (5) | 170 ± 71 (5) | |
| Alkaline phosphatase (U/L) | 57 ± 19 (5) | 30 ± 23 (5) | 190 ± 56††† (5) | 80 ± 40‡ (5) | |
| Creatinine (µmol/L) | 16 ± 4 (5) | 17 ± 3 (5) | 20 ± 3 (5) | 28 ± 6 (5) | |
| Urea (mmol/L) | 8.3 ± 1.3 (5) | 6.5 ± 0.9 (5) | 8.5 ± 0,6 (5) | 6.8 ± 2.4 (5) | |
| Uric acid (µmol/L) | 75 ± 33 (5) | 51 ± 20 (5) | 140 ± 35† (5) | 160 ± 110 (5) | |
| Total protein (g/L) | 49 ± 2 (5) | 53 ± 4 (5) | 46 ± 5 (5) | 52 ± 5 (5) | |
Non-fasting blood samples were used for the measurements. Significances p < 0.05, < 0.01 and < 0.001 are indicated for comparisons between WT on CD vs WT on KD (*, ** and ***), WT on CD vs Bcs1l G/G on CD (†, ††, †††) and Bcs1l G/G on CD vs Bcs1l G/G on KD (‡, ‡‡, ‡‡‡), respectively. n numbers in brackets.