Table 3.
HEK293 cells | Bias factor | mLTC-1 cells | Bias factor |
---|---|---|---|
ß-arrestin 2/cAMP | 1.81 (p = 0.0655) | cAMP/Progesterone | 5.25 (p = 0.0034) |
Cre -reporter assay/cAMP | 4.84 (p = 0.0000177) | cAMP/Testosterone | 2.39 (p = 0.0301) |
Cre -reporter assay/ß-arrestin 2 | 2.67 (p = 0.00988) | Testosterone/Progesterone | 2.19 (p = 0.0617) |
The bias factor values of each response pair reflect the biased agonism of rhLH towards the first response compared to the second, all in comparison to rhCG taken as the reference hormone.