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. 2017 Apr 19;7:915. doi: 10.1038/s41598-017-01003-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced IOP and increased outflow facilities in miR-143/145 dKO mice. (A) Reduced intraocular pressure (IOP) in miR-143/145 dKO mice. ***p < 0.0001; (B) Reduced intraocular pressure in miR-143/145 dKO mice in an experimental glaucoma model. The IOP of the mice was measured at 1 and 2 weeks after microbeads injection into the eye. ***p < 0.0001; (C) Significant increase in outflow facilities in 16-month-old miR-143/145 dKO mice compared to that in WT control mice. ***p < 0.0006.