Table 1.
Effect of Ad-TOP-dn-N-cad on HSV Organ Cultures
| Ad-β-gal | Ad-TOP-dn-N-cad | |
|---|---|---|
| Total number of intimal cells/mm | 10.0 ± 1.5 | 3.9 ± 1.0a |
| Intimal proliferation (%) | 18.7 ± 6.8 | 19.7 ± 3.7 |
| Medial proliferation (%) | 7.3 ± 2.1 | 7.9 ± 2.6 |
| Migration (% BrdU −ve/mm) | 0.042 ± 0.09 | 0.040 ± 0.005 |
| Medial apoptosis | 12.3 ± 5.4 | 13.3 ± 4.6 |
Segments of human saphenous vein were infected with Ad-TOP-dn-N-cad or Ad-β-gal and cultured for 7 days prior to analysis, n = 6.
a
Indicates significant difference (paired Student’s t test, p < 0.05).