Figure 4.

Respiratory Chain Activity in Optic Nerves from DBA/2J Mice at Various Ages

The enzymatic activities of complexes I, II + III, III, IV, and V were measured in single ONs isolated from DBA/2J mice of different ages, namely 2, 5, 8, 10 to 12, and 14 to 16 months. The values in each histogram represent the mean ± SEM of triplicates (CI and CV) or of duplicates (CII + CIII and CIII and CIV) for the samples evaluated; the CI/CV ratio is also shown. p values were calculated with respect to the activity assessed in 2-month-old DBA/2J mice. The age of the group in months (m) and the number of independent measurements performed is shown beneath each bar.