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. 2017 Apr 20;7:978. doi: 10.1038/s41598-017-00981-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Simultaneous recording of network activity and intracellular activity. (a) Visualization of the array area (dashed box), and the corresponding SSAM. A neuron (position indicated by pipette drawing) was recorded intracellularly, while spontaneous extracellular activity was recorded by sparsely distributed electrodes (all recording electrodes are marked with black spots, while circled dots indicate the subset of electrodes, the signals of which are shown in (b)). (b) Top: Extracellular signals (detected spikes) of 24 electrodes distributed over the array at the locations of the circled dots in (a). Bottom: Intracellular signal of the patched neuron. The close-up shows an individual, enlarged PSP (scale bars 100 ms/4 mV).