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. 2017 Apr 20;7:919. doi: 10.1038/s41598-017-01032-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EBOV challenge results in larger transcriptional changes in animals that succumb to infection compared to those that survive. (a) Bar graph: Number of DEGs detected 4, 7 (or the day animals were necropsied), 14, 35 and 42 dpi in negative control, CD4-depleted, positive control, and CD8-depleted animals. Line graph: Total number of RPKM normalized transcripts mapping to the Kikwit-ZEBOV genome. Longitudinal changes of EBOV transcripts were carried out using one-way repeated measures ANOVA test followed by Dunnett’s multiple comparison post-test to determine differences between day 0 and subsequent days post-infection; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; n = 4 in all groups. (b,c) Principal component analysis of all 4 groups 4 (B) and 7 (C) dpi.