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. 2017 Apr 20;7:919. doi: 10.1038/s41598-017-01032-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Negative control and CD4-depleted animals show transcriptional changes consistent with hemorrhagic fever on the day they succumb to EBOV challenge. (a) Venn diagram comparing upregulated and downregulated genes in negative control and CD4-depleted animals on the day of euthanasia. (b,c) Bar graph depicting the most statistically significant GO terms to which upregulated DEGs in negative control animals (b) and CD4-depleted animals (c) enriched on the day of euthanasia. (d) Network depicting direct interactions of common upregulated genes between negative control and CD4-depleted animals that map to “Immune System Process”. (e,f) Bar graph depicting the most statistically significant GO terms to which downregulated DEGs in negative control animals (e) and CD4-depleted animals (f) enriched on the day of euthanasia (g) Network depicting direct interactions of downregulated genes in both groups that map to “Cellular Metabolic Process”.