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. 2017 Apr 20;7:1097. doi: 10.1038/s41598-017-00957-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cellular uptake and cytotoxicity of CA IX-TPL-Lips in NSCLC A549 cells. (a) Confocal laser scanning microscopy image of CA IX-negative and CA IX-positive A549 cells after treatment with NBD-DPPE labeled CA IX-Lips and non-targeted liposomes for 4 h; Scale bars, 10 μm. (b) Quantitative analysis of NBD-DPPE-labeled liposomes uptake by flow cytometry. (c) Mean fluorescence intensity of NBD-DPPE-labeled liposomes after 4 h treatment; control cells were untreated. Data are presented as mean ± SD (n = 3), ***Indicates p < 0.001. (d) In vitro cytotoxicity of free TPL, non-targeted TPL-Lips and CA IX-TPL-Lips against CA IX-positive and CA IX-negative A549 cells assessed by MTT assay. Data are presented as mean ± SD (n = 3). *p < 0.05 compared with free TPL group; ^#p < 0.05 compared with non-targeted TPL-Lips group.