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. 2017 Apr 20;7:981. doi: 10.1038/s41598-017-01056-0

Figure 2.

Figure 2

Reduction of MAPD90 prolongation by Tetrodotoxin (TTX) and eleclazine (Elec) in hearts treated with Bay K 8644 alone and ATX-II plus Bay K 8644. (a) Representative recordings of MAPs recorded from the epicardium of the left ventricular wall in serially exposed to no drug (control, curve 1), ATX-II (3 nM, curve 2), ATX-II plus Bay K 8644 (200 nM, curve 3), ATX-II plus Bay K 8644 plus TTX (1 µM, curve 4), and ATX-II plus Bay K 8644 plus eleclazine (10 µM, curve 5). (b) Concentration-dependent decreases by TTX of epi-MAPD90 and endo-MAPD90 in the presence of 300 nM Bay K 8644 (n = 7). (c) Effect of TTX (1 µM) and eleclazine (10 µM) on the increase of Δ epi-MAPD90 and Δ endo-epi MAPD90 induced by Bay K 8644 in absence and presence of ATX-II. * P < 0.05 vs. control (ctrl); # P < 0.05 vs. Bay K 8644; † P < 0.05 vs. ATX-II; & P < 0.05 vs. ATX-II plus Bay K 8644.