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. 2017 Apr 20;7:981. doi: 10.1038/s41598-017-01056-0

Figure 6.

Figure 6

Bay K 8644 increased I CaL. TTX and eleclazine reduced both endogenous and enhanced late I Na. (a) and (b) Representative recordings of I CaL in control (Ctrl, a) and in a cell treated with Bay K 8644 (300 nM, b). (c) Summarized data of various concentrations of Bay K 8644 to increase the density of I CaL in rabbit ventricular cells. * P < 0.05 vs. control. (d) and (e) Representative recordings of late I Na in a cell in Ctrl, and after treatment with either TTX (1 µM, d) or eleclazine (Elec, 10 µM, e). (f) and (g) Representative recordings of late I Na in a cell in Ctrl, before (Bay K 8644 300 nM alone) and after treatment with either TTX (f) or Elec (g). (h) and (i) Representative recordings of late I Na in a cell in Ctrl, before (ATX-II 3 nM) and after treatment with either TTX (1 µM, h) or Elec (10 µM, i) in the continued presence of ATX-II. (j) Summarized data of TTX and Elec on the density of late I Na in Ctrl and in cells treated with either Bay K 8644 (300 nM) or ATX-II (3 nM). * P < 0.05 vs. Ctrl; # P < 0.05 vs. Bay K 8644; † P < 0.05 vs. ATX-II.