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. 2017 Apr 20;7:936. doi: 10.1038/s41598-017-01039-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Joint inter-spike interval (ISI) distribution heatmaps comparing one ISI (y-axis, ms) with the following ISI (x-axis, ms). Heatmaps in column 1 were compiled from 5 stimulus presentations per animal either before treatment (1A,B, n = 25), or 24 hours after treatment with the vehicle (1C,D, n = 10). 2–3A,B were recorded from 80 to 110 minutes after treatment with 10 ng/g (n = 5) or 100 ng/g (n = 20) IMD. 2–3C,D were recorded 24 hours after treatment with 10 ng/g (2C,D, n = 10) and 100 ng/g (3C,D, n = 10).