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. 2017 Apr 20;7:944. doi: 10.1038/s41598-017-01062-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Female, but not male, GPR55 KO mice display decreased thermal paw withdrawal latencies to hot plate stimulation. Female GPR55 KO mice displayed decreased withdrawal latencies to the onset of nociceptive behavior in the hot plate assay at 50 °C and 55 °C relative to female WT mice. Data are expressed as mean ± SEM (n = 9–15 per group). Two-way ANOVA, one-tailed t-test. **p < 0.01, *p < 0.05 vs. female WT.