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. 2017 Apr 20;7:944. doi: 10.1038/s41598-017-01062-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GPR55 KO and WT mice display comparative levels of capsaicin-evoked nocifensive behavior, mechanical and thermal hyperalgesia. (a) A trend toward higher levels of capsaicin-evoked nocifensive behavior was observed in GPR55 KO relative to WT mice but (b) no difference in nocifensive behavior was observed between genotypes in mice receiving vehicle (i.pl.). Data are expressed as mean ± SEM (n = 6 per group). 2-tailed t-test. Levels of capsaicin-evoked (c) thermal and (e) mechanical hypersensitivity do not differ between GPR55 KO and WT mice. (d) Thermal paw withdrawal latencies and (f) mechanical paw withdrawal thresholds did not differ between GPR55 KO and WT mice receiving vehicle (i.pl.). Data are expressed as mean ± SEM (n = 6 per group). 2-way ANOVA.