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. 2017 Apr 20;7:944. doi: 10.1038/s41598-017-01062-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CFA elicits comparable levels of mechanical and thermal hypersensitivity in GPR55 KO and WT mice. Levels of CFA-evoked mechanical hypersensitivity do not differ between GPR55 KO and WT mice (a). CFA does not elicit mechanical hypersensitivity in the paw contralateral to CFA administration (b). Paw diameters were similar in the CFA-injected (ipsilateral) paw in GPR55 KO and WT mice (c). Paw diameters were elevated in GPR55 KO relative to WT mice in the paw contralateral to CFA administration on day 7 only (d). Data are expressed as mean ± SEM (n = 8–9 per group). ***p < 0.001 vs. WT, 2-way ANOVA, Bonferroni post-hoc. In an independent replication, GPR55 KO and WT mice develop similar levels of mechanical (e), and thermal hypersensitivity (g) following i.pl. CFA. Mechanical (f), and thermal (h) hyperalgesia do not develop in the paw contralateral to CFA administration. Data are expressed as mean ± SEM (n = 8 per group). 2-way ANOVA.