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. 2017 Apr 20;7:971. doi: 10.1038/s41598-017-01065-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment of donor corneas with IL-10 and TGFβ1 increases corneal allograft survival. Donor corneas received a single subconjunctival injection of IL-10/TGFβ1 or saline (control) two days prior to grafting. Corneal transplantation (N = 10–16/group) was performed onto inflamed graft beds. Weekly examination of grafts until 8 weeks post-transplantation revealed (A) decreased graft opacity scores (p = 0.0011) and (B) increased graft survival in IL-10/TGFβ1-treated grafts compared to saline-treated controls (68.7% vs. 0%, p < 0.0001). Error bars show standard error of mean.