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. 2017 Apr 20;7:992. doi: 10.1038/s41598-017-01019-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electron microscopic analyses of intercostal neuromuscular junctions in rhesus monkeys. Transmission electron micrographs showing representative nerve boutons of 3 animals, either before (‘Prescreening’, a,b,c) or seven days after challenge with IgG4Δhinge-637 (d), IgG1-637 (e) or the combination of IgG4Δhinge-637 and IgG1-637 (f). Each micrograph has the dimension of 5 × 6 µm. Asterisks indicate nerve terminals/boutons and arrowheads point at the (intact) primary synaptic clefts. Arrows point to normal secondary postsynaptic clefts/folds; the daggers in panel e indicate widening of the primary synaptic cleft, where the presynaptic and the postsynaptic membrane were separated from each other. (g) The folding index (length of postsynaptic membrane/length of the corresponding presynaptic membrane), a measure of the degree of postsynaptic folding. (h) Blinded scoring of the normal versus widened synaptic clefts.