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. 2017 Apr 20;7:992. doi: 10.1038/s41598-017-01019-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantitative Immunofluorescent analysis of NMJ endplates in rhesus monkey intercostal biopsies. Biopsies were obtained from each animal before (“Pre”) or 7 days after antibody challenge with IgG4Δhinge-637, IgG1-637 or the combination of both. (a) Representative photomicrographs from the four groups showing staining of the AChR (detected by alpha-bungarotoxin fluorescence), IgG (IgG + IgG4Δhinge), the membrane attack complex (MAC) and a merged image to show colocalization. Relative fluorescence intensities (RFU) of (b) MAC staining and (c) human IgG staining was normalized with AChR expression in individual endplates. Intensities were quantitated in a total of 589 endplates (5-158 endplates per biopsy) and averaged per biopsy. The number n indicates the number of animals/biopsies analyzed for each condition. Data represent means ± SEM.