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. 2017 Apr 20;7:935. doi: 10.1038/s41598-017-01110-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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STE suppresses EV71-induced ROS generation. RD cells were mock- or infected with BrCr, 1743, and 4643 at m. o. i. of 0.05 for 1 hr, and subsequently treated with indicated concentrations of STE for 24 h. Cells were loaded with H₂DCFDA at 37 °C for 30 min, and analyzed cytometrically. Data are means ± SD of six separate experiments. ***P < 0.0001, vs. infected cells without treatment.