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Response to IR in normal vs steatotic liver. Induction of antioxidant systems in the normal liver facilitates survival in response to preconditioning protocols. Reduced PGC-1α activity in the steatotic liver limits antioxidant induction and results in extensive hepatocyte cell death. IR, Ischemia-Reperfusion; IPC, Ischemic Preconditioning; and ROS, Reactive Oxygen Species.
