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. 2017 Apr 21;7:1020. doi: 10.1038/s41598-017-01093-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Aminoglycoside mediated rescue of signalling properties of nonsense mutated LEPR-b variants. HEK293 cells were co-transfected with either (a,b) mLepr-b ^W31X- (inset mLepr-b ^wt), (c,d) mLepr-b ^Y333X- or (e,f) mLepr-b ^Y763X-pcDNA3.1 overexpression construct, STAT3-RE-PLuc and phRG-b. Two days after the transfection, cells were treated for 24 h with different concentrations of the aminoglycosides and for the last 16 h in addition with 6 nM murine leptin (n = 4, SD). Statistical significance between (−) and (+) leptin was assessed by t-tests with Bonferroni-Holm correction for multiple comparisons *p < 0.05; **p < 0.01; ***p < 0.001.