Table 1.

Leptin receptor nonsense mutations.

Nonsense mutation	Species	PTC ± 6 bp context	Protein
W16X	human*	ACT CCT TGA AGA TTT	TPXRF
	mouse	TCT CCC TGA AAA TTT	SPX KF
Y333X	mouse	GTT GTG TAA TTT CCA	VVXFP
Y763X	rat*	AAT GAT TAA AGT CTG	NDXSL
	mouse	GAT GAT TAA AGT CTG	DDXSL

Three different point mutations resulting in the formation of premature termination codons (PTC) were investigated in the present study. All mutations were inserted into the murine receptor sequence to ensure a comparison within an identical genetic backbone. The mutation W31X was additionally investigated within the human sequence. Differences on the nucleotide and amino acid level are underlined.

*Indicates the species in which the mutation was identified.