Table 1.
Baseline demographics, body mass index, clinical, cognitive, biochemical and imaging parameters in preclinical (CDR = 0) mutation carriers (MCs) and non-carriers (NCs).
| NCs (N = 110) | MCs (N = 120) | P-value | |
|---|---|---|---|
| Age | 36.7 (7.9) | 35.3 (8.0) | 0.238a |
| Gender (M/F) no. | 49/72 | 64/88 | 0.789b |
| Education (years) | 13.2 (0.4) | 13.4 (0.6) | 0.735a |
| GDS | 1.3 (1.8) | 1.6 (1.9) | 0.248c |
| EYO | −11.8 (7.1) | −11.5 (6.7) | 0.759a |
| BMI, kg/m2 | 30.1 (5.9) | 26.5 (5.2) | 0.0001 a |
| BMI < 18.5 (%) | 1.1 | 2.1 | 0.984b |
| BMI ≥ 18.5 to <25.0 (%) | 24.7 | 34.0 | 0.165b |
| BMI ≥ 25.0 to <30.0 (%) | 30.3 | 38.1 | 0.263b |
| BMI ≥ 30 (%) | 43.8 | 25.8 | 0.009 b |
| Stroke (%) | 1.1 | 0 | 0.443d |
| Diabetes (%) | 2.2 | 0 | 0.195d |
| Hypertension (%) | 16.9 | 5.4 | 0.010 d |
| Hypercholesterolemia (%) | 11.2 | 15.2 | 0.533d |
| MMSE score | 29.1 (1.5) | 29.1 (1.4) | 0.695a |
| LogMem I | 15.01 (4.2) | 13.8 (4.8) | 0.037a |
| LogMem II | 13.9 (4.4) | 12.03 (5.3) | 0.003 a |
| Global PIB-uptake | 1.03 (0.1) | 1.7 (0.8) | <0.0001 a |
Note: Displayed are means and standard deviations (SD); MCs = mutation carriers; NCs = non mutation carriers; aANCOVA comparisons at Bonferroni adjusted p < 0.006 level of significance; bPearson chi-square test; cMann-Whitney U test; dFisher’s exact test; CDR = Clinical Dementia Rating scale; M = male; F = female; GDS = Geriatric Depression Scale; BMI = body mass index; no. = number; % = percentage; EYO = estimated years to symptom onset; MMSE = Mini-Mental State Examination; LogMem I = Logical Memory test, immediate recall; LogMem II = Logical Memory test, delayed recall; Global PIB-uptake = global cerebral Aβ burden as measured by 11C-Pittsburgh Compound-B PET.