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. 2017 Apr 26;7:1179. doi: 10.1038/s41598-017-01325-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of IL-1β in the CA3 hippocampal region and the thalamus of mice under acute status epilepticus. Anti-HMGB1 mAb, control IgG or PBS was administered intravenously when mice reach Racine stage 5 by pilocarpine administration and sacrificed 4 h later. The brains were fixed by formalin and paraffin-embedded sections were stained with anti-IL-1β antibody. The hippocampal CA3 (a) and thalamus region (d) were under observation. The number of highly IL-1β immunoreactive cells (b) and the fluorescence intensity (c) were analyzed in hippocampus CA3. **p < 0.01 compared with the sham group. ^&p < 0.05 compared with the PBS group. ^##p < 0.01, ^#p < 0.05 compared with the control IgG group. The results are shown as the means ± SEM of 8 mice. The number of highly IL-1β immunoreactive cells (e) and the fluorescence intensity (f) were analyzed in thalamus. The results are shown as the means ± SEM of 8 mice. **p < 0.01, *p < 0.05 compared with sham group. ^&&p < 0.01, ^&p < 0.05 compared with the PBS group. ^##p < 0.01, ^#p < 0.05 compared with the control IgG group (d). Scale bars equal 50 μm.