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. 2017 Apr 28;7:1288. doi: 10.1038/s41598-017-01379-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification and phenotypic characterization of NKG2D⁺CD4⁺ T cells in SLE. (A) FCM assay of NKG2D expression among CD4⁺ T, CD8⁺ T, NK and NKT cells in representative peripheral blood samples from a representative HC and SLE patient. (B) Frequency profiles of NKG2D expression on CD4⁺ T, CD8⁺ T, CD3⁻CD56⁺ NK and CD3⁺CD56⁺ NKT cells in the HCs (n = 46) and SLE patients (n = 66). Each symbol represents one individual. (C) NKG2D⁺CD4⁺ T cells were gated from a representative peripheral blood sample of an SLE patient and analyzed for expression of the indicated surface markers (black-lined histograms). Gray-filled histograms represent the staining with control Ab. (D) FCM assay of the expression of the indicated markers in gated CD4 cells from a representative peripheral blood sample of an SLE patient and statistical analysis of the frequency of the of CD4⁺ T cell subset in PBMCs of SLE patients (n = 30) and HCs (n = 30), respectively. Numbers represent percentages. Each symbol represents one individual; ^** P < 0.01, ^*** P < 0.001. Horizontal lines with bars show the mean ± SD.