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. 2017 Apr 21;7:1014. doi: 10.1038/s41598-017-00936-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Up-regulation of the PERK/Nrf2 pathway in sciatic nerve of STZ-induced DPN rats by TLN. (A) The relative expression of p-PERK, Nrf2 and γGCS determined by double-immunostaining 12 weeks after TLN treatment. (B) Representative Western blot of GRP78, Keap1 and HO-1 12 weeks after TLN treatment (Left panel), and the relative fold changes of GRP78, Keap1 and HO-1. (C) The serum levels of NQO1 and GST 12 weeks after TLN treatment. NQO1 was detected using the ELISA kit. GST activity was determined using a colorimetric method. Data are shown as mean ± S.E.M. ^Δ P < 0.05, ^ΔΔ P < 0.01 vs. Normal group; ^# P < 0.05, ^## P < 0.01 vs. DPN group. Data were analyzed by One-way ANOVA followed by least significant difference or Tambane’s T2 analysis (n = 6 animals per group).