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. 2017 Apr 21;7:1014. doi: 10.1038/s41598-017-00936-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Downregulation of CHOP, Bax, Caspase-3 and upregulation of Bcl-2 in sciatic nerve of STZ-induced DPN rats by TLN treatment. (A) and (C) Representative Western blots of Bcl-2, Bax, CHOP and Caspase-3 12 weeks after TLN treatment (Left panel). (B) and (D) The relative levels of Bcl-2, Bax, CHOP and Caspase-3 (Right panel). Data are shown as mean ± S.E.M. ^Δ P < 0.05, ^ΔΔ P < 0.01 vs. Normal group; ^# P < 0.05, ^## P < 0.01 vs. DPN group. Data were analyzed by One-way ANOVA followed by least significant difference or Tambane’s T2 analysis (n = 6 animals per group).