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. 2017 Apr 21;7:1005. doi: 10.1038/s41598-017-00691-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depletion of SSH1 is correlated with diminished STAT1 activation. (a/b) Immature DCs were generated and transfected with a control siRNA or siRNA directed against SSH1. 72 hours post transfection, cells were stimulated with IL-10 (30 ng/ml) for the indicated time points and STAT activation was analysed by Western Blot. Tyrosine phosphorylation of STAT1 and STAT3 was detected by specific antibodies. To control for equal loading, total STAT protein was detected. One out of four independent experiments (a) and quantification of four experiments (b) are shown. Data represent mean and SD. For statistical analysis a one-way ANOVA with Tukey’s post hoc test was performed.