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. 2017 Apr 24;7:1085. doi: 10.1038/s41598-017-01121-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mice lacking SLC10A4 demonstrates decreased mast cell-mediated responses in vivo. (A,B) Wild type (WT) BALB/c and Slc10a4 ^−/− littermates were sensitized by intradermal injection of anti-OVA IgE (left ear) and PBS (right ear). The following day, all mice were given OVA in Evans Blue dye intravenously in the tail. (A) Representative pictures of WT and Slc10a4 ^−/− mice and ears. (B) The quantifications of extravasated Evans Blue dye per mg tissue from 10–11 individual mice per group from a representative experiment out of two. Asterisks mark significant differences (*P < 0.05, **P < 0.01) using a paired Student’s t-test. (C–E) WT and Slc10a4 ^−/− mice were given intradermal neck injections of substance 48/80, histamine or saline (NaCl) as vehicle and their scratching behaviour was recorded during 60 min and analysed for the number of scratching events and the duration of each scratching event (bout time). (C) The bout time pattern from a representative WT and Slc10a4 ^−/− mouse after activation by 48/80. Each dot represents a scratching event. (D,E) The data shown are the mean ± SEM of 10 mice per group genotype and treatment (48/80, histamine or NaCl) from a single experiment. Asterisks mark significant differences (*P < 0.05) using a standard unpaired Student’s t-test.