Table 1.

Pharmacokinetic parameters of Hup-A in normal, saline- and cycloheximide-treated rats after oral administration of suspension and SMEDDS.

Group		Pharmacokinetic parameter
		Cmax (ng/mL)	Tmax (h)	AUC (ng·h/mL)
Normal ratsa	SMEDDS	3.42±0.45*	1.07±0.16	21.07±4.59**
	Suspension	2.41±0.39	0.51±0.11	10.05±2.70
Saline-treated ratsb	SMEDDS	3.45±0.42	1.03±0.54	20.16±4.42&&
	Suspension	2.44±0.31	0.49±0.10	9.97±2.65
Cycloheximide- treated ratsb	SMEDDS	2.18±0.28#	1.01±0.37	12.09±3.06##
	Suspension	2.16±0.23	0.50±0.11	9.50±2.25

Data are expressed as mean±SD, n=6.

^aBioavailability study.

^bLymphatic transport study.

^*P<0.05,

^**P<0.01 versus suspension in rats;

^#P<0.05,

^##P<0.01 versus SMEDDS in saline-treated rats as the control;

^&&P<0.01 versus suspension in saline-treated rats.