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. 2017 Apr 21;7:1007. doi: 10.1038/s41598-017-01249-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CsA and DEX treatment affects the methylation change and mRNA expression of IRF8 in active VKH patients. (A) The mRNA expression of IRF8 was detected by real-time PCR in DCs with or without the treatment with CsA or DEX. DCs were obtained from active VKH patients (n = 8, *p < 0.05). The methylation changes shown in CpG_1 (B), CpG_7.8 (C) and CpG_16 (D) of CsA treated and DEX treated DCs were significantly decreased compared to the untreated DCs from active VKH patients (n = 8, *p < 0.05, **p < 0.01, ***p < 0.001). The data are shown as mean ± SEM. One way-ANOVA, followed by Bonferroni correction was used to compare the mRNA level and methylation changes among multiple groups.