Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 21;7:1007. doi: 10.1038/s41598-017-01249-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

DAC affects the production of inflammatory cytokines by DCs from VKH patients. CD14⁺ monocytes from VKH patients and normal controls were cultured for 6 days and then stimulated with 100 ng/ml LPS for 24 hours. The protein concentrations of IL-6, IL-1β, IL-23 and IL-12p70 in the supernatants were determined by ELISA. (A) The expression of IL-6, IL-1β, IL-23 and IL-12p70 was significantly increased in VKH patients compared with normal controls (n = 12, *p < 0.05,**p < 0.01, ***p < 0.001). (B) The protein concentrations of IL-6, IL-1β, IL-23 and IL-12p70 were reduced if cells (from VKH patients) were pretreated with 10 µM of DAC (n = 12, *p < 0.05). The data are shown as mean ± SEM. The paired-samples t-test was performed for the statistical analysis.