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. 2017 Apr 26;7:1210. doi: 10.1038/s41598-017-01264-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sequential TGF-β1:receptor complex formation in the presence of different HA derivatives. (A) Schematic drawing of the experimental set-up showing that TβR-II was immobilized on a C1 Sensor Chip and all other components were injected in the order: TGF-β1, GAG or buffer, TβR-I. Binding of TβR-I to TβR-II/TGF-β1 in the presence of (B) polymeric HA and sHA3 or (C) HA dp4 and psHA dp4. The sensorgrams display one representative experiment out of at least three independent measurements. Binding levels for the association of TβR-I to the complex of TβR-II/TGF-β1 including the indicated (D) polymeric or (E) tetrameric GAGs were ranked. Values represent the mean ± SD of n = 3. One-way ANOVA: *p < 0.05; **p < 0.01 vs. control or HA.