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. 2017 Apr 25;7:1112. doi: 10.1038/s41598-017-01148-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Double-stranded DNA accelerates microvascular thrombosis in vivo. Thrombus formation in vivo was investigated by phototoxic (light/dye-induced) vessel injury of microvessels in the mouse cremaster muscle. Intrascrotal injection of poly(dA:dT) (5 µg DNA 12 hours prior to the experiment) resulted in a more rapid onset of thrombus formation in arterioles (a) but not in venules (c). Time to complete vessel occlusion was significantly accelerated after poly(dA:dT) injection in both arterioles (b) and venules (d). (e) Representative images show thrombus formation in mouse cremaster arterioles (20 min after start of injury) and mouse cremaster venules (10 min after start of injury) with markedly increased thrombus formation in poly(dA:dT) treated animals (right pictures) as compared to control animals (left pictures). Scale bar is 50 µm. (*P < 0.05 vs. control, n = 6 animals each).