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. 2017 Apr 21;7:1070. doi: 10.1038/s41598-017-01090-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Subnetworks generated by VizMapper for each comparison −50 ppm F vs. Control Group. Color of node indicates the differential expression of the respective protein, for each comparison. Red nodes indicate protein down-regulation. Gray node indicates proteins presenting interaction but that were not identified in the present study. The access numbers in grey nodes correspond to: Putative RNA exonuclease NEF-sp (A1A5R7), PIN2/TERF1-interacting telomerase inhibitor 1 (A4L691), Aplp1 protein (B1WBV6), Mthfd1l protein (B2GUZ3), Mothers against decapentaplegic homolog 2 (O70436), Transthyretin (P02767), Protein kinase C epsilon type (P09216), Tumor necrosis fator-TNF (P16599), Mitogen-activated protein kinase 3-Mapk3 (P21708), Beta-arrestin-1 (P29066), Melatonin receptor type 1A (P49218), 14-3-3 protein gamma (P63102), 40S ribosomal protein S8 (P62243), 14-3-3 protein epsilon (P62260), 40S ribosomal protein S13 (P62278), Growth factor receptor-bound protein 2 (P62994), 14-3-3 protein zeta/delta (P63102), Unconventional myosin-Vb (P70569), Glutamate receptor ionotropic, NMDA 2B (Q00960), Ripk2 protein (Q3B7U0), Tubulin beta-3 chain (Q4QQS4), Transducin beta-like protein 3 (Q5U2W5), Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 (Q5U2Z4), Nuclear factor NF-kappa-B p105 subunit (Q63369), Von Hippel-Lindau disease tumor supressor (Q64259), Translation initiation factor eIF-2B subunit alpha (Q64270), Serine/threonine-protein kinase PAK 2 (Q64303), Polyglutamine-binding protein 1 (Q6PCT5), Cb1-727 (Q7TP21), Protein quaking (Q91XU1), E3 ubiquitin-protein ligase TRIM63 (Q91Z63), Epidermal growth factor receptor related protein (Q91Z63), Epidermal growth factor receptor related protein (Q9ESE0), Drebrin-like protein (Q9JHL4), Casein kinase 1 epsilon (Q9JJ76), and Inhibitor of nuclear factor kappa-B kinase subunit beta (Q9QY78). The access numbers in green nodes correspond to: 78 kDa glucose-regulated protein (P06761), 40S ribosomal protein S14 (P13471), Enoyl-CoA hydratase, mitochondrial (P14604), 60S ribosomal protein L6 (P21533), and 40S ribosomal protein S3 (P62909). The names of the proteins corresponding to each access number in the red nodes are listed in the Supplementary Table S2.